Determination of Metformin Hydrochloride in Different Brands of Tablets Commercially Available in the Libyan Pharmaceutical Market

Salwa Thabat; Muna Othman; Hana Saeid; Ghandoura Ahlaal

doi:10.54361/ajmas.261104

Authors

Salwa Thabat Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, Al-Bayda, Libya. https://orcid.org/0009-0007-1121-6981
Muna Othman Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, Al-Bayda, Libya. https://orcid.org/0009-0001-5939-090X
Hana Saeid Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, Al-Bayda, Libya. https://orcid.org/0000-0003-3344-9376
Ghandoura Ahlaal Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omar Al-Mukhtar University, Al-Bayda, Libya. https://orcid.org/0009-0000-2581-4199

DOI:

https://doi.org/10.54361/ajmas.261104

Keywords:

Spectrophotometer, Metformin Hydrochloride, Quantity

Abstract

Metformin hydrochloride is an oral hypoglycemic drug used to treat type 2 diabetes mellitus and belongs to the class of Biguanides. This study assessed and compared the pharmaceutical quality of four brands of metformin hydrochloride tablets produced by different manufacturers and available in the Libyan pharmaceutical market, using United States Pharmacopoeia (USP) specifications as the reference standard. The active pharmaceutical ingredient content was quantified using ultraviolet–visible (UV–Vis) spectrophotometry. Assay values ranged from 83.3% to 100% of the labelled content. Three brands met the USP acceptance criteria, whereas one did not comply with the specified requirement. These findings indicate that the evaluated products varied in their compliance with pharmacopeial standards and highlight the need for regular post-marketing quality surveillance to identify substandard medicines and support patient safety.