Alterations of lipid Profile and Minerals induced by Ketoprofen and the Potential role of Ganoderma lucidum in male Albino Rats

Ameerah Ramadhan; Khadija Abogtisha; Marfoua Saleh; Nura Al-Zail; Eda Alshailabi

doi:10.54361/ajmas.269719

Authors

Ameerah Ramadhan Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya https://orcid.org/0009-0002-3757-2187
Khadija Abogtisha College of Medical Technology / Ajdabiya, Libya https://orcid.org/0009-0008-5813-9597
Marfoua Saleh Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya https://orcid.org/0000-0002-1401-3027
Nura Al-Zail Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya https://orcid.org/0000-0001-6997-8064
Eda Alshailabi Department of Zoology, Faculty of Science, Omar Al-Mukhtar University, El-Beyda, Libya https://orcid.org/0000-0002-1588-5556

DOI:

https://doi.org/10.54361/ajmas.269719

Keywords:

Lipid Profile, Minerals, Ketoprofen, Ganoderma Lucidum, and Male Rats

Abstract

The non-steroidal anti-inflammatory drug called ketoprofen lowers fever and inflammation. Ganoderma lucidum has maintained its status as one of the most prominent medicinal herbs due to its association with health. This work aimed to find out alterations of lipid parameters and minerals induced by Ketoprofen and the potential role of Ganoderma lucidum. A total of twenty male albino rats were utilized in this study, randomly separated into four groups, with five rats in each group. Group 1: The standard laboratory conditions were maintained for the five members in the regular control group. Group 2: Ketoprofen group (KP); KP was administered orally by gavage every day in the morning within two weeks at a dosage of fifty milligrams per kg of body weight (BW). Group 3: Ganoderma lucidum (G.L) was given reishi mushroom by oral gavage every morning for four weeks in the morning at a dosage of three hundred milligrams per kilogram of BW. Group 4: A combination group (KP-G.L). For two weeks, animals received KP by swallowing at a dose of fifty milligrams per kilogram of BW. The animals were receiving G.L by oral gavage every morning for 4 weeks at a dose of 300 milligrams per Kg of BW following a two-week KP treatment. The KP had varying effects on the studied measurements. This led to significant changes, like a decline in overall body weight and folate, levels of ferritin, zinc (Zn), triglyceride (TG), and vitamin D (VD) levels. Meanwhile, it caused an increase in total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). The treatment also led to an increase in calcium (Ca) levels. As for the Ganoderma lucidum, the therapy led to a decrease in total weight without significant differences. It also caused a reduction in the level of ferritin and LDL. However, it caused a rise in levels of TC, TG, very low-density lipoprotein (VLDL), and HDL. And an increase in the level of Zn, Ca, and VD. In the combination group, all previous parameters were returned to close to normal values.