Screening for Analgesic and Anti-Inflammatory Effect of Antioxidants by Applying Formalin Test Using Albino Mice

Authors

  • Aburawi S*, Al Tubuly R, Friwan A, Al-Ghdamsi M Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Libya

Keywords:

Antioxidant, Vitamin C, Vitamin E, Selenium, Formalin Test

Abstract

Objective: Aim of this work is to evaluate analgesic and anti-inflammatory effects of antioxidants. Methods: Formalin test was applied using albino mice. This model constitutes two distinct phases: the first phase represents the irritating effect of formalin at the sensorial fiber-C, while the second phase is inflammatory pain response. Results: Vitamin C, vitamin E and selenium have analgesic effect for neuropathic pain. Vitamin E and selenium produce anti-inflammatory effect.Conclusion: Analgesic effect for neuropathic pain was observed with vitamin C, vitamin E and selenium treatment. Anti-inflammatory effect is produced by vitamin E and selenium administration; while Vitamin C produces insignificant decrease in inflammation in the dose used.

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Published

2017-07-08

How to Cite

1.
Aburawi S*, Al Tubuly R, Friwan A, Al-Ghdamsi M. Screening for Analgesic and Anti-Inflammatory Effect of Antioxidants by Applying Formalin Test Using Albino Mice. Alq J Med App Sci [Internet]. 2017 Jul. 8 [cited 2024 Oct. 13];1(1):1-8. Available from: https://journal.utripoli.edu.ly/index.php/Alqalam/article/view/106

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